Rational Design of COVID-19 Drug Leads from Cancer Therapeutics
Although the COVID-19 pandemic has eased, the virus continues to evolve. The development of new, targeted antiviral drugs remains crucial for preparedness against future outbreaks. This research began with drug repurposing screening, which revealed that lapatinib—an approved breast cancer drug—can bind to and inhibit the main protease (Mpro) of SARS-CoV-2, a key enzyme required for …
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