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Contemporary medical diagnosis relies on sensors, particularly enzyme-based electrochemical biosensors, to detect disease markers due to their high specificity and sensitivity. However, enzymes as biomolecules denature over time, causing the sensor being less reliable. This research aims to develop hydrogels capable of decreasing the rate of enzyme denaturation in order to extend a lifetime of …

Hydrogel for preserving activity of enzyme for electrochemical biosensor Read More »

This work investigates the mechanism of a Rh(I)-catalyzed transformation of primary alcohols and butadiene into saturated branched ketones, without premetalated intermediates or external hydrogen sources. DFT calculations reveal a four-step pathway involving alcohol oxidation, butadiene hydrogenation, carbonyl addition, and intramolecular hydrogen transfer. The rate-determining step is the sterically hindered carbonyl addition, which also explains why …

Mechanistic study on the conversion of primary alcohols and butadiene into branched ketones using a rhodium catalyst Read More »

With more and more used lithium-ion batteries piling up, how can we recycle lithium safely and sustainably? Our team developed a special solvent called a Deep Eutectic Solvent (DES) — made from harmless, low-toxicity chemicals — to extract lithium quickly and selectively from battery waste. This DES is hydrophobic, works at room temperature, takes only …

Extracting Lithium the Greener Way Read More »

Gas chromatography (GC) is increasingly applied for efficient separation of volatile compounds in complex samples. While online meetings can support research communication, method development, and training, they often lack the interactive engagement needed to sustain participation. To address this, we propose a metaverse platform that is immersive, interactive, and globally accessible. The system integrates GC …

Insights into Application of Metaverse and Virtual Platforms with Gas Chromatography Read More »

Using untargeted metabolomics, researchers uncovered the mechanisms underlying the battle between the plant wilt pathogen Ralstonia solanacearum and the biocontrol microbe Bacillus amyloliquefaciens BNC5. Normally, BNC5 produces antimicrobial macrolactins to eliminate its competitors. However, when exposed to substances secreted by R. solanacearum, the macrolactin profile shifted, resulting in reduced inhibitory efficacy. Interestingly, the researchers found …

Ralstonia solanacearum Secretions Induce Shifts in Macrolactin Composition and Reduction in Antimicrobial Activity of Bacillus amyloliquefaciens BNC5 Read More »

Accurate, non-invasive monitoring of creatinine is essential for assessing kidney function, with elevated levels indicative of chronic kidney disease (CKD). Sweat creatinine serves as a promising biomarker for kidney health. Similarly, sweat glucose monitoring is critical for detecting metabolic imbalances, particularly in diabetic kidney disease (DKD). Simultaneous detection of these biomarkers is vital for early …

Non-invasive fingertip sweat biosensor for early kidney disease biomarker screening Read More »

Arsenic in water is a serious environmental concern because it is highly toxic. To help detect this dangerous substance, a new and easy-to-use method has been developed under the Environmental Analysis Research Unit (EARU) for the colorimetric detection of arsenite (As(III)) in water using ferric ion (Fe(III))- assisted tartrate-stabilized gold nanoparticles. When arsenic is in …

Colorimetric detection of arsenic(III) using iron(III) assisted tartrate stabilized gold nanoparticles Read More »

As artificial intelligence (AI)  continues to transform medicine and pharmaceuticals, its role in accelerating the discovery of bioactive compounds is becoming increasingly crucial.  A research team led by Assoc. Prof. Dr. Tanatorn Khotavivattana from the Department of Chemistry, Faculty of Science, Chulalongkorn University, in collaboration with experts from multiple institutions, designed and synthesized 89 flavone derivatives, …

Training AI to Predict Anticancer Activity from Rationally Designed Flavones Read More »