Microbial plant pathogens pose a significant threat to agriculture, causing extensive crop losses and reducing food security. Traditional methods of combating these pathogens often rely on chemical pesticides, which can have detrimental environmental effects and lead to resistant pathogen strains. Therefore, there is a growing need for sustainable and effective alternatives. This research aims to combat microbial plant pathogens by harnessing novel natural products derived from rhizospheric microbe-microbe interactions. These interactions are a rich source of unique compounds with potential antimicrobial properties. Initially, we will identify and isolate natural products produced by interactions between biocontrol microbes, microbial plant pathogens, and other rhizospheric microbes using LC-MS-based untargeted metabolomic analyses. The antimicrobial activities of these isolated products will then be tested against plant pathogens, and their effects will be evaluated in plant pots and field trials. Furthermore, we will study the biosynthetic and stimulated mechanisms of these natural products using RT-PCR and other appropriate techniques. This research seeks to offer innovative and sustainable solutions for managing plant diseases, enhancing crop health, and improving agricultural productivity.