Faculty of Science, Chulalongkorn University, Thailand
Know more about us
For anyone who is interested in our graduate programs at the Department of Chemistry, Faculty of Science, Chulalongkorn University, you can now watch a recorded live Active Recruitment 2024 program
- Introducing new faculty member Dr. Tatchamapan Yoskamtorn Feb 2, 2024
- Introducing new faculty member Dr. Waleed Alahmad Dec 1, 2023
- Introducing new faculty member Dr. Supacha Wirojsaengthong Dec 1, 2023
- BSAC graduate has been awarded MSc scholarship from Tokyo Metropolitan University (TMU) Nov 13, 2023
- CHEM SEE YOU CAMP Nov 1, 2023
- Lecture on “How to handle and store chemicals in warehouse safely” Sep 25, 2022
- งานปฐมนิเทศนิสิตใหม่ปริญญาตรีชั้นปีที่ 1 Jul 7, 2022
- รับสมัครทุนพสวท.สำหรับนิสิตปริญญาบัณฑิตศึกษา Jul 6, 2021
- ปฐมนิเทศนิสิตใหม่ ระดับปริญญาตรี Jun 16, 2021
- ยินดีต้อนรับว่าที่นิสิตใหม่จากระบบ TCAS 64 May 27, 2021
- The admission for graduate programs in Chemistry and Green Chemistry and Sustainability for the first semester of academic year 2024 is now open. Jan 27, 2024
- The admission for graduate study for Round 1 of the second semester academic year 2023 is now open. Aug 7, 2023
- The admission for graduate study in green chemistry and sustainability for Round 2 of the first semester academic year 2023 is now open. Mar 19, 2023
- The admission for graduate study in chemistry for Round 2 of the first semester academic year 2023 is now open. Mar 19, 2023
- The admission for graduate study in chemistry for Round 1 of the first semester academic year 2023 is now open. Feb 1, 2023
Ten undescribed benzophenones, schomburginones A− J, together with 14 known analogs were isolated from the leaves of Garcinia schomburgkiana, an edible plant native to the Indochina region. The structures of the undescribed compounds were elucidated by NMR combined with HRMS spectroscopy, while their absolute configurations were determined using ECD and single-crystal X-ray diffraction analysis. The isolated metabolites represent benzophenone derivatives containing a modified monoterpene unit, including tri- and tetracyclic skeletons, which are rarely found in genus Garcinia. The cytotoxic evaluation on three cancerous cell lines demonstrated that schomburginone G, schomburginone H, and 3-geranyl-2,4,6-trihydroxybenzophenone were active against HeLa cells with IC50 values in the range of 12.2–15.7 μM, respectively, and selective compared to the non-cancerous L929 cells (SI > 3.5). In addition, the three cytotoxic compounds together with clusiacyclol A showed significant NO inhibitory activity in RAW 264.7 macrophage cells over 85% inhibition without obvious cytotoxicity at a final concentration of 100 μM. The promising activities of these compounds in cytotoxic and anti-inflammatory assays make them attractive for further study in the development of anticancer drugs.