A Novel PDMS-Based Digital Magnetofluidic Platform for Lab-on-a-Chip Applications

Superhydrophobic gold film embedded PDMS was employed as a novel platform for digital magnetofluidics. The device performance for lab-on-a-chip applications was investigated by demonstrating four types of reactions: (i) acid-based titration as a simple mixing reaction, (ii) colorimetric detection of phosphate based on the molybdenum blue method as a more complicated reaction, (iii) colorimetric detection of glucose using glucose oxidase as an enzymatic reaction and (iv) multistep analysis of C-reactive protein (CRP) based on immunomagnetic separation. Results from the four reaction types confirmed that the superhydrophobic gold-coated PDMS has shown its ability to be a simple platform for digital magnetofluidics for a variety of applications in the field of lab-on-a-chip technology.